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| Status |
Public on Apr 30, 2008 |
| Title |
Genes regulated by miR-34b/c and DAC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC.
Keywords: dose response
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| Overall design |
A colorecal cancer cell line HCT116 was transfected with miR-34b or -c precursor or negative control. Also, HCT116 was treated with 5-aza-2'-deoxycytidine (DAC) or mock. Genes up- or downregulated by miR-34b/c and those by DAC was compared.
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| |
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| Contributor(s) |
Suzuki H, Toyota M, Tokino T |
| Citation(s) |
18519671 |
| |
| Submission date |
Feb 09, 2008 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Hiromu Suzuki |
| E-mail(s) |
hsuzuki@sapmed.ac.jp
|
| Phone |
+81-11-611-2111
|
| Organization name |
Sapporo Medical University
|
| Department |
Department of Molecular Biology
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| Street address |
S1, W17, Chuo-ku
|
| City |
Sapporo |
| State/province |
Hokkaido |
| ZIP/Postal code |
060-8556 |
| Country |
Japan |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA108009 |
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