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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 12, 2018 |
| Title |
Transcriptomic dataset after cisplatin induced acute kidney injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Cisplatin-induced acute kidney injury (AKI) is one of the most common and severe side effects and can prevent the use of this important agent. Unfortunately, preventive or therapeutic tools to address cisplatin-induced AKI are lacking. Interestingly, in the last decades a row of preconditioning strategies that employ the activation of cellular stress resistance pathways have been shown to be promising approaches to protect from organ injury in rodent models. Here, we characterized both the protective potential and the underlying molecular patterns of two strategies – caloric restriction and hypoxic preconditioning – in mice treated with cisplatin.
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| Overall design |
mRNA profiles of mouse kidney after cisplatin injection with preconditioning baseline, caloric restriction and hypoxia.
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| Contributor(s) |
Späth MR, Bartram MP, Palacio-Escat N, Hoyer KR, Debes C, Schroeter C, Beyer A, Benzing T, Schermer B, Burst V, Saez-Rodriguez J, Huesgen PF, Müller R, Rinschen MM, Demir F, Mandel AM, Grundmann F, Ciarimboli G, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Höhne M |
| Citation(s) |
30522767 |
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| Submission date |
Nov 16, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Andreas Beyer |
| Organization name |
University of Cologne
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| Department |
System Biology
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| Lab |
Beyer lab
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| Street address |
Joseph-Stelzmann-Str. 26
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| City |
Cologne |
| ZIP/Postal code |
50931 |
| Country |
Germany |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA418754 |
| SRA |
SRP125104 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE106993_expNameNom.csv.gz |
3.6 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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