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| Status |
Public on Mar 05, 2008 |
| Title |
Time course of NHBE cells exposed to whole cigarette smoke (full flavor) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression patterns were assessed in normal human bronchial epithelial (NHBE) cells exposed to cigarette smoke (CS) from a typical "full flavor" American brand of cigarettes in order to develop a better understanding of the genomic impact of tobacco exposure, which can ultimately define biomarkers that discriminate tobacco-related effects and outcomes in a clinical setting. NHBE cells were treated with CS for 15 minutes and alterations to the transcriptome assessed at 1,2,4 and 24 hours post-CS-exposure using high-density oligonucleotide microarrays.
Keywords: Time course
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| Overall design |
Cells were exposed to smoke or air (“mock-exposed”) for 15 min, after which they were refed with fresh media and allowed to incubate for 1h, 2h, 4h or 24h. Smoke and mock samples were compared at each time point.
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| Contributor(s) |
Jorgensen ED, Albino AP |
| Citation(s) |
18694499 |
| |
| Submission date |
Mar 04, 2008 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Ellen Jorgensen |
| E-mail(s) |
ejorgensen@vectorgroupltd.com
|
| Organization name |
Vector Research Ltd.
|
| Street address |
712 Fifth Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10019 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA107605 |
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