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| Status |
Public on Mar 01, 2009 |
| Title |
Prevalence of Copy-number neutral LOH in glioblastomas revealed by analysis of laser-microdissected tissues |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
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| Summary |
We have employed a laser capture microdissection technique and single nucleotide polymorphism arrays to characterize genomic alterations associated with the development of glioblastomas. Combined analysis of LOH and copy number revealed that more than half of the identified 254 LOH loci showed no copy number alteration, indicating the presence of copy-number neutral LOH
Keywords: DNA copy number, Loss of heterozygosity
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| Overall design |
Affymetrix 50K SNP mapping arrays were used to profile 14 primary glioblastomas (GBMs) with matched blood DNA samples. Loss of heterozygosity (LOH) and copy number abnormality (CNA) profiles were derived from each tumour-blood pair.
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| Contributor(s) |
Kuga D, Kukita Y, Hayashi K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 24, 2008 |
| Last update date |
Dec 22, 2017 |
| Contact name |
DAISUKE KUGA |
| Organization name |
Kyushu University
|
| Street address |
3-1-1, Maidashi, Higashi-ku
|
| City |
Fukuoka |
| State/province |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL2005 |
[Mapping50K_Xba240] Affymetrix Human Mapping 50K Xba240 SNP Array |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA107227 |
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