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Series GSE10924 Query DataSets for GSE10924
Status Public on Mar 25, 2008
Title CD4+ T Cell Decline is Predicted by Differential Expression of Genes in HIV seropositive patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Patterns of expressed genes examined in cryopreserved peripheral blood mononuclear cells (PBMCs) of seropositive persons electing to stop antiretroviral therapy in the AIDS Clinical Trials Group Study A 5170, were scrutinized to identify markers capable of predicting the likelihood of CD4+ T cell depletion after cessation of ART.
Two cohorts were matched for clinical characteristics in a study of the effects of therapy interruption (TI) in ART-treated patients with immunological preservation. Disease progression was determined by CD4+ T cell count decline 24 weeks after TI.Gene Set Enrichment Analysis (GSEA) identified a set of genes in the Ras signaling pathway, associated with the downregulation of apoptosis, as significantly upregulated in the good outcome group at cessation of ART.
Keywords: Disease state analysis
 
Overall design There are 96 samples in this study. 24 patients with good outcome results and 24 matched patients with poor outcome results. Each patient has two time points: week0 and week 24
 
Contributor(s) Vahey M
Citation(s) 18724805
Submission date Mar 24, 2008
Last update date Jul 08, 2016
Contact name Maryanne Vahey
E-mail(s) mvahey@hivresearch.org
Phone 301-251-5058
Fax 301-762-7460
Organization name Walter Reed Army Institute of Research
Department
Lab Laboratory of Functional Genomics
Street address 1600 East Gude Drive
City Rockville
State/province MD
ZIP/Postal code 20850
Country USA
 
Platforms (1)
GPL201 [HG-Focus] Affymetrix Human HG-Focus Target Array
Samples (96)
GSM276899 Patient 101141 at week 0
GSM276900 Patient 101141 at week 24
GSM276901 Patient 101774 at week 0
Relations
BioProject PRJNA107231

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10924_RAW.tar 71.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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