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| Status |
Public on May 02, 2008 |
| Title |
Genome-wide analysis of estrogen receptor binding sites |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation,particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer.
Keywords: estrogen effect, time course
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| Overall design |
This Series currently contains the gene expression data accompaning Carroll JS et al. Nature Genetics 38,1289-1297(2006). MCF7 cells were stimulated with 100 nM estrogen for 0, 3, 6, or 12h. All experiments were performed in triplicate.
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| Web link |
http://research.dfci.harvard.edu/brownlab/datasets/index.php?dir=ER_whole_human_genome/
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| Contributor(s) |
Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M |
| Citation(s) |
17013392 |
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| Submission date |
May 02, 2008 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Scott Andrew Ochsner |
| E-mail(s) |
sochsner@bcm.edu
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| Phone |
713-798-6227
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| Organization name |
Baylor College of Medicine
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| Department |
Molecular and Cellular Biology
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| Lab |
SPP: Signaling Pathways Project
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| Street address |
One Baylor Plaza
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA106643 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE11324_RAW.tar |
102.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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