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| Status |
Public on Apr 19, 2018 |
| Title |
RNA splicing in the transition from B cells to antibody secreting cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The purpose of this study was to explore the splicing landscape in unstimulated versus stimulated B cells in both ELL2 sufficient and deficient mice. This would allow us to see the magnitidue of splicing changes in the transition from unstimulated to stimulated B cells, as well as the importance of ELL2 in this process.
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| Overall design |
We analyzed 15 mouse B cell samples. Four of the samples were replicates for wild type unstimulated B cells, four were unstimulated ELL2-/- B cells, four were +LPS wild type stimulated B cells collected @ 72 hours, and the final three were +LPS ELL2-/- stimulated B cells collected @ 72 hours.
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| Contributor(s) |
Milcarek C, Nelson AM |
| Citation(s) |
30297340, 30544499 |
| |
| Submission date |
Apr 18, 2018 |
| Last update date |
Jan 15, 2019 |
| Contact name |
Christine Milcarek |
| E-mail(s) |
milcarek@pitt.edu
|
| Organization name |
University of Pittsburgh
|
| Department |
Immunology
|
| Street address |
200 Lothrop Street
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21341 |
[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [probeset (exon) CDF version] |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA450826 |
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