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| Status |
Public on May 17, 2008 |
| Title |
CD8 T cells stimulated with IL-2 complex in vivo |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
IL-2 signals into CD8 T cells have a programming and regulatory role in driving cells to full effector and memory differentiation. This study was designed to look for IL-2 target genes that affect CD8 T cell responses.
Keywords: Time-course, cytokine treatment
Keywords: Expression profiling by array
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| Overall design |
Treatment of mice with IL-2/anti-IL-2 immune complexes (IL-2 complex) stimulates all fraction of CD8 T cells in vivo. Because STAT5 phosphorylation peaked 1 h after injection of the IL-2 complex, gene expression in CD8 T cells was compared at 0 h (no treatment), 1 h and 3 h post treatment. Two mice were used for each time point.
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| Contributor(s) |
Kamimura D, Bevan MJ |
| Citation(s) |
18832700 |
| |
| Submission date |
Sep 03, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Michael J Bevan |
| Organization name |
Univerisity of Washington, HHMI
|
| Department |
Immunology
|
| Lab |
Bevan
|
| Street address |
I604H HSC, 1959 NE Pacific Street
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98195-7370 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (3) |
| GSM288809 |
CD8 T cells_IL-2 complex treatment_0 h |
| GSM288810 |
CD8 T cells_IL-2 complex treatment_1 h |
| GSM288811 |
CD8 T cells_IL-2 complex treatment_3 h |
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| Relations |
| BioProject |
PRJNA106475 |
