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Series GSE11882 Query DataSets for GSE11882
Status Public on Oct 09, 2008
Title Gene expression changes in the course of normal brain aging are sexually dimorphic
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This dataset of cognitively normal controls is a subset of the GSE48350 dataset, which additionally contains microarray data from AD brains.

Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain aging emerged, revealing two overarching concepts. First, different regions of the forebrain exhibited substantially different gene profile changes with age. For example, comparing equally powered groups, 5,029 probe sets were significantly altered with age (20-59 vs. 60-99) in the superior frontal gyrus, compared with 1,110 in the entorhinal cortex. Prominent change occurred in the 6th-7th decades across cortical regions, suggesting that this period is a critical transition point in brain aging, particularly in males. Second, clear gender differences in brain aging were evident across the lifespan, suggesting that the brain undergoes sexually dimorphic changes in gene expression not only in development but also in later life. Globally across all brain regions, males showed more gene change than females. Further, Gene Ontology analysis revealed that different categories of genes were predominantly affected in males vs. females. Notably, the male brain was characterized by global decreased catabolic and anabolic capacity with aging, with downregulated genes heavily enriched in energy production and protein synthesis/transport categories. Increased immune activation was a prominent feature of aging in both sexes, with more widespread activation in the female brain. These data open new opportunities to explore age-dependent changes in gene expression that set the balance between neurodegeneration and compensatory mechanisms in the brain, and suggest that this balance is set differently in males and females, an intriguing and novel idea.

Keywords: Normal gene expression patterns across the adult lifespan
 
Overall design Postmortem brain tissue from 4 brain regions [hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG)] of cognitively intact humans (age 20-99) was collected from ADRC brain banks. Cases were preferentially selected where 3 or more brain regions were available. HgU133plus2.0 microarray chips were used to profile gene expression.
Note that this dataset of cognitively normal controls is a subset of the GSE48350 dataset, which contains data from these cognitively normal controls, and from AD cases. The control and AD cases were processed simultaneously (tissue collection, RNA extraction, microarray processing).
 
Contributor(s) Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW
Citation(s) 18832152, 23273601, 22824372, 23999428, 23206327, 24268883, 29207277
Submission date Jun 25, 2008
Last update date May 03, 2022
Contact name Nicole Claudia Berchtold
E-mail(s) nberchto@uci.edu
Phone 949 824 6071
Organization name UC Irvine
Department Institute for Memory Impairments and Neurological Disorders
Lab Carl W. Cotman
Street address 1226 Gillespie Neuroscience Facility
City Irvine
State/province CA
ZIP/Postal code 92697-4540
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (173)
GSM300166 PostcentralGyrus_female_91yrs_indiv10
GSM300167 SuperiorFrontalGyrus_female_91yrs_indiv10
GSM300168 Hippocampus_female_96yrs_indiv105
Relations
BioProject PRJNA105699

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Supplementary file Size Download File type/resource
GSE11882_RAW.tar 847.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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