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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 08, 2009 |
| Title |
Liver gene expression profiling of complement component 3a receptor 1 knockout (C3ar1-/-) mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Complement component 3a receptor 1 (C3ar1) was predicted as a causal gene for abdominal using a novel statistical method named LCMS (Schadt et al., 2005, Nature Genetics). In order to validate this prediction, we profiled the liver tissues of complement component 3a receptor 1 knockout (C3ar1-/-) mice and their littermate wild-type (wt) controls to examine the gene expression signature as well as pathways/networks resulting from the single gene perturbation.
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| Overall design |
3 C3ar1-/- mice and 4 wt controls were profiled. Reference pool included RNA extracted from the liver of 6 wt control mice. Dye-swap was involved in the profiling.
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| Citation(s) |
19270708 |
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| Submission date |
Jul 03, 2008 |
| Last update date |
Mar 19, 2012 |
| Contact name |
Xia Yang |
| E-mail(s) |
xia.yang@sagebase.org
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| Phone |
206-667-2118
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| Organization name |
Sage Bionetworks
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| Street address |
1100 Fairview Ave N
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| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
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| Platforms (1) |
| GPL3562 |
Rosetta/Merck Mouse TOE 75k Array 1 microarray |
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| Samples (7)
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| GSM303269 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar1 WT Chow Diet-1 |
| GSM303270 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar1 WT Chow Diet-2 |
| GSM303271 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar1 WT Chow Diet-3 |
| GSM303272 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar1 WT Chow Diet-4 |
| GSM303273 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar (-/-) KO Chow Diet -2 |
| GSM303274 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar (-/-) KO Chow Diet -3 |
| GSM303275 |
Liver, WT Chow Diet Control pool (n=6) vs. Liver, C3ar (-/-) KO Chow Diet -4 |
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| This SubSeries is part of SuperSeries: |
| GSE12000 |
Obesity study in transgenic and knockout animals |
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| Relations |
| BioProject |
PRJNA109235 |
| Supplementary data files not provided |
| Processed data included within Sample table |
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