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| Status |
Public on Sep 08, 2009 |
| Title |
Gene expression of human paediatric osteosarcoma tumour samples relative to normal human osteoblasts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions.
Cancer-specific changes in gene expression play an essential role in cancer occurrence, and ultimately lead to cancer-related self-sufficiency in growth signals, insensitivity to growth inhibitory signals, evasion of apoptosis, limitless replicative potential, angiogenesis, and metastasis. We aimed to analyse such changes in gene expression related to osteosarcoma.
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| |
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| Overall design |
We performed genome-wide comparison of gene expression and identified genes that are differentialy expressed in osteosarcoma tumour samples relative to normal human osteoblasts (HOB)
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| |
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| Contributor(s) |
Sadikovic B |
| Citation(s) |
19286668 |
| |
| Submission date |
Sep 19, 2008 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Bekim Sadikovic |
| E-mail(s) |
bsadikov@gmail.com
|
| Organization name |
The SickKids Hospital and Princess Margaret Hospital
|
| Street address |
555 University Avenue
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5G 1X8 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE12885 |
Genome-wide changes in DNA methylation and copy number play a role in deregulation of gene expression in osteosarcoma |
|
| Relations |
| BioProject |
PRJNA114173 |
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