 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Oct 24, 2008 |
| Title |
Rb1 deficient Apc1638N cecal tumors vs duodenal tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To examine the role of Rb1 in gastrointestinal (GI) tumors we generated mice with an Apc1638N allele, Rbtm2brn floxed alleles, and a villlin-cre transgene (RBVCA). These mice had reduced median survival due to an increase in tumor incidence and multiplicity in the cecum and the proximal colon; they differed from murine intestinal tumors of the Apc1638N type which normally arise solely in the small intestine. We have examined by micro-array analysis three cecal tumors from these mice (probable adenomas), and compared them to three duodenal tumors (probable adenocarcinomas). Expression profiles of duodenal and cecal tumors relative to each other show unique gene subsets up and down regulated. The two tumor types were subsequently shown to differentially regulate distinct sets of genes over expressed in a majority of human colorectal carcinomas.
|
| |
|
| Overall design |
We have compared 3 cecal tumors with 3 duodenal tumors from Rb1 deficient Apc1638N mice.
|
| |
|
| Contributor(s) |
Kucherlapati M, Yang K, Fan K, Kuraguchi M, Sonkin D, Rosulek A, Lipkin M, Bronson RT, Aronow BJ, Kucherlapati R |
| Citation(s) |
18832169 |
| |
| Submission date |
Oct 21, 2008 |
| Last update date |
May 04, 2018 |
| Contact name |
Dmitriy Sonkin |
| Organization name |
Novartis Institutes for BioMedical Research
|
| Street address |
250 Massachusetts Avenue
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
|
| Samples (6)
|
| GSM335823 |
duodenal tumor, biological replicate 1 |
| GSM335824 |
duodenal tumor, biological replicate 2 |
| GSM335825 |
duodenal tumor, biological replicate 3 |
| GSM335826 |
cecal tumor, biological replicate 1 |
| GSM335827 |
cecal tumor, biological replicate 2 |
| GSM335828 |
cecal tumor, biological replicate 3 |
|
| Relations |
| BioProject |
PRJNA109869 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE13298_RAW.tar |
13.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...