|
| Status |
Public on Oct 01, 2009 |
| Title |
Antitumor efficacy of RAF inhibitor GDC-0879 involving BRAFV600E mutational status and ERK/MAPK pathway suppression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Unsupervised hierarchical clustering revealed a strong similarity in gene modulation resulting from either compound treatment or BRAF ablation mediated by RNA interference relative to DMSO-treated control samples .
Keywords: Expression Array
|
| |
|
| Overall design |
We have generated melanoma A375 cells stably expressing a shRNA construct for doxycycline-inducible knockdown of B-Raf (2 mg/ml Dox, 48h). Small molecule treatment was at 1000nM R341787, 24h.
|
| |
|
| Contributor(s) |
Modrusan Z, Haverty P, Hoeflich K |
| Citation(s) |
19276360 |
| |
| Submission date |
Nov 05, 2008 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Peter Haverty |
| E-mail(s) |
phaverty@gene.com
|
| Organization name |
Genentech, Inc.
|
| Department |
Bioinformatics
|
| Street address |
1 DNA Way
|
| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (30)
|
|
| Relations |
| BioProject |
PRJNA110165 |
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