|
Status |
Public on Oct 01, 2009 |
Title |
Antitumor efficacy of RAF inhibitor GDC-0879 involving BRAFV600E mutational status and ERK/MAPK pathway suppression |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
|
Summary |
Unsupervised hierarchical clustering revealed a strong similarity in gene modulation resulting from either compound treatment or BRAF ablation mediated by RNA interference relative to DMSO-treated control samples .
Keywords: Expression Array
|
|
|
Overall design |
We have generated melanoma A375 cells stably expressing a shRNA construct for doxycycline-inducible knockdown of B-Raf (2 mg/ml Dox, 48h). Small molecule treatment was at 1000nM R341787, 24h.
|
|
|
Contributor(s) |
Modrusan Z, Haverty P, Hoeflich K |
Citation(s) |
19276360 |
|
Submission date |
Nov 05, 2008 |
Last update date |
Mar 25, 2019 |
Contact name |
Peter Haverty |
E-mail(s) |
phaverty@gene.com
|
Organization name |
Genentech, Inc.
|
Department |
Bioinformatics
|
Street address |
1 DNA Way
|
City |
South San Francisco |
State/province |
CA |
ZIP/Postal code |
94080 |
Country |
USA |
|
|
Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
Samples (30)
|
|
Relations |
BioProject |
PRJNA110165 |