|
| Status |
Public on Dec 31, 2009 |
| Title |
Influenza virus infected HUVEC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To delineate specific patterns of signaling networks activated by H5N1 we used a comparative systems biology approach analyzing gene expression in endothelial cells infected with three different human and avian influenza strains of high and low pathogenicity.
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| Overall design |
HUVECs were infected with either PR8, FPV or H5N1 virus. We used wildtype HUVEC or HUVEC transfected with a dominant negative mutant of IKK2 (block of the NF-kB signaling pathway). In case of FPV infections we also blocked p38 MAP kinase with an SB-inhibitor.
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| Contributor(s) |
Viemann D, Schmolke M, Lueken A, Boergeling Y, Friesenhagen J, Wittkowski H, Ludwig S, Roth J |
| Citation(s) |
19786538, 21106851 |
| |
| Submission date |
Nov 18, 2008 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Dorothee Viemann |
| E-mail(s) |
Viemann.Dorothee@mh-hannover.de
|
| Phone |
+49-511-532 - 7823
|
| Organization name |
Hannover Medical School
|
| Department |
Department of Pediatric Pulmonology, Allergy and Neonatology
|
| Street address |
Carl-Neuberg-Straße 1
|
| City |
Hannover |
| State/province |
Deutschland |
| ZIP/Postal code |
30625 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (30)
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| Relations |
| BioProject |
PRJNA110185 |
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