|
| Status |
Public on Sep 03, 2021 |
| Title |
Transcriptomic and epigenetic analysis of adipose tissue in Cushing Syndrome [human] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Chronic glucocorticoids (GCs) exposure, resulting from endogenous Cushing Syndrome (CS) or prescribed GCs therapy, is associated with a high cardiometabolic burden. Moreover, previous studies have reported persistence of metabolic syndrome features after remission of hypercortisolism and in particular in visceral adipose tissue (VAT). Thus, in this study we want to analyze the transcriptomic alterations in VAT during active and cured CS and correlate these persistent gene expression changes with changes in histone modifications induced by GCs.
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| |
|
| Overall design |
RNA-seq (18 samples) and ChIP-seq (26 samples) of human visceral adipose tissue. CS means human patients of Cushing and CTL controls.
|
| |
|
| Contributor(s) |
Garcia G, Hanzu F, Vizan P, Gonzalez-Ramirez M |
| Citation(s) |
34487152 |
| |
| Submission date |
Nov 08, 2019 |
| Last update date |
Dec 04, 2021 |
| Contact name |
Mar Gonzalez-Ramirez |
| E-mail(s) |
mar.bellvisgonzalez@gmail.com
|
| Organization name |
Center for Genomic Regulation (CRG)
|
| Street address |
C/ Dr Aiguader 88
|
| City |
Barcelona |
| ZIP/Postal code |
08003 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (44)
|
|
| Relations |
| BioProject |
PRJNA588382 |
| SRA |
SRP229337 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE140126_H3K27ac_DPeaks_results.txt.gz |
746.6 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K27ac_Peaks_CS_results.txt.gz |
523.1 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K27ac_Peaks_CTL_results.txt.gz |
758.3 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K27me3_DPeaks_results.txt.gz |
92.6 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K27me3_Peaks_CS_results.txt.gz |
27.6 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K27me3_Peaks_CTL_results.txt.gz |
107.1 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K4me3_DPeaks_results.txt.gz |
566.2 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K4me3_Peaks_CS_results.txt.gz |
470.8 Kb |
(ftp)(http) |
TXT |
| GSE140126_H3K4me3_Peaks_CTL_results.txt.gz |
614.7 Kb |
(ftp)(http) |
TXT |
| GSE140126_RAW.tar |
3.6 Gb |
(http)(custom) |
TAR (of BED, BEDGRAPH) |
| GSE140126_human_FPKMs.txt.gz |
3.1 Mb |
(ftp)(http) |
TXT |
| GSE140126_human_results.txt.gz |
1.2 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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