|
| Status |
Public on Dec 21, 2021 |
| Title |
NEK2 regulates triple negative breast cancer transcriptome. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
NEK2 is a mitotic kinase that is upregulated and mislocalized in the nucleus of human cancer cells. NEK2 modulates expression and activity of both transcription and splicing factors in cancer cells, nevertheless whether this kinase affects transcriptome regulation genome widely and whether this activity concurs to its oncogenic activity is still unknown. Herein, by high-throughput RNA sequencing analysis of MDA-MB-231 cells transiently silenced for NEK2 we uncover an extensive modulation of triple-negative breast cancer cell transcriptome by this kinase.
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| |
|
| Overall design |
RNA‐Seq data for MDA-MB-231 cells, transiently silenced for NEK2
|
| |
|
| Contributor(s) |
Naro C, de La Grange P, Sette C |
| Citation(s) |
34930366, 35530315 |
| |
| Submission date |
Nov 21, 2019 |
| Last update date |
May 11, 2022 |
| Contact name |
Pierre de la Grange |
| E-mail(s) |
pierre.delagrange@genosplice.com
|
| Organization name |
GenoSplice technology
|
| Department |
Paris Biotech Santé
|
| Street address |
29, rue du Faubourg Saint-Jacques
|
| City |
Paris |
| ZIP/Postal code |
75014 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA590988 |
| SRA |
SRP231163 |
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