|
| Status |
Public on Feb 01, 2020 |
| Title |
Tissue responses to Shiga toxin in human intestinal organoids |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Intestinal tissue responses to protein synthesis inhibition by Shiga toxin are complex. Organoid models allow for an unprecedented examination of human tissue responses to a deadly Shiga toxin.
|
| |
|
| Overall design |
Comparison of RNA profile for gene upregulation and downregulation in organoids microinjected with PBS and Shiga toxin.
|
| |
|
| Contributor(s) |
Weiss AA, Pradhan S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 31, 2020 |
| Last update date |
Feb 19, 2020 |
| Contact name |
Alison A Weiss |
| E-mail(s) |
weissaa@ucmail.uc.edu
|
| Phone |
5135582820
|
| Organization name |
University of Cincinnati
|
| Department |
COM Molecular Genetics
|
| Lab |
Weiss lab
|
| Street address |
231 Albert Sabin Way
|
| City |
Cincinnati |
| State/province |
Ohio |
| ZIP/Postal code |
45267 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL15433 |
Illumina HiSeq 1000 (Homo sapiens) |
|
| Samples (12)
|
| GSM4292579 |
Injected with PBS as control-4hr [PB4a] |
| GSM4292580 |
Injected with PBS as control-4hr [PB4b] |
| GSM4292581 |
Injected with PBS as control-4hr [PB4c] |
| GSM4292582 |
Injected with Shiga toxin-4hr [ST4a] |
| GSM4292583 |
Injected with Shiga toxin-4hr [ST4b] |
| GSM4292584 |
Injected with Shiga toxin-4hr [ST4c] |
| GSM4292585 |
Injected with PBS as control-24hr [PB24a] |
| GSM4292586 |
Injected with PBS as control-24hr [PB24b] |
| GSM4292587 |
Injected with PBS as control-24hr [PB24c] |
| GSM4292588 |
Injected with Shiga toxin-24hr [ST24a] |
| GSM4292589 |
Injected with Shiga toxin-24hr [ST24b] |
| GSM4292590 |
Injected with Shiga toxin-24hr [ST24c] |
|
| Relations |
| BioProject |
PRJNA604235 |
| SRA |
SRP246356 |
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