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| Status |
Public on Apr 18, 2009 |
| Title |
Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Whereas estrogens exert their effects by binding to nuclear estrogen receptors and directly altering target gene transcription, they can also initiate extranuclear signaling through activation of kinase cascades.
We have investigated the impact of estrogen-mediated extranuclear initiated pathways on global gene expression by using estrpgen-dendrimer conjugates.
Keywords: ligand treatment
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| Overall design |
MCF-7 human breast adenocarcinoma cells were treated with empty dendrimer control, E2, or Estrogen Dendrimer Conjugate (EDC) for 4 hours, and cDNA microarray analyses were carried out using Affymetrix HG-U133A GeneChips
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| |
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| Contributor(s) |
Erdogan ZM, Katzenellenbogen B |
| Citation(s) |
18617595 |
| |
| Submission date |
Apr 17, 2009 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Zeynep Madak Erdogan |
| Organization name |
UIUC
|
| Department |
FSHN
|
| Lab |
Zeynep Madak Erdogan
|
| Street address |
1201 S Goodwin Ave
|
| City |
Urbana |
| State/province |
IL |
| ZIP/Postal code |
61801 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA116609 |
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