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| Status |
Public on Oct 19, 2020 |
| Title |
RNASeq analysis to unravel molecular networks driving leukemia in Ebf1+/-Pax5+/- (dHet) B-ALL mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To profile gene expression changes in Ebf1+/-Pax5+/- (dHet) leukemic mice, we performed RNASeq analysis in dHet B-ALL, dHet proB and wt proB cells.
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| Overall design |
Leukemic cells derived from the lymph node of three dHet B-ALL mice (686,713 and 760), a short term culture of proB cells derived from dHet pre-leukemic mice and wt proB cells were used for the RNASeq analysis.
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| |
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| Contributor(s) |
Ramamoorthy S, Bayer M, Kometani K, Boller S, Grosschedl R |
| Citation(s) |
33004416 |
| |
| Submission date |
Sep 28, 2020 |
| Last update date |
Oct 19, 2020 |
| Contact name |
Senthilkumar Ramamoorthy |
| E-mail(s) |
senthilkumar@ie-freiburg.mpg.de
|
| Phone |
00497615108731
|
| Organization name |
Max Planck Institute of Immunobiology and Epigenetics
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| Department |
Cellular & Molecular Immunology
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| Lab |
Laboratory Rudolf Grosschedl
|
| Street address |
Stübeweg 51
|
| City |
Freiburg |
| ZIP/Postal code |
D-79108 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE158673 |
EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression and folate metabolism |
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| Relations |
| BioProject |
PRJNA666155 |
| SRA |
SRP285633 |
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