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| Status |
Public on Oct 19, 2020 |
| Title |
ATACSeq and genome-wide binding profile of EBF1 and Pax5 to unravel molecular networks driving leukemia in Ebf1+/-Pax5+/- (dHet) B-ALL mice. |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
ATACSeq, EBF1 ChIPSeq and Pax5 ChIPSeq of dHet B-ALL, dHet proB and wt proB cells.
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| Overall design |
ATACSeq, EBF1 ChIP and Pax5 ChIP were performed on the pro-B cell lines and dHet B-ALL cell lines. The pro-B cell lines were established by culturing c-Kit+ fetal liver cells of Ebf1+/+ Pax5+/+ Rag2-/- or Ebf1+/-Pax5+/-Rag2-/- cells. Ebf1+/-Pax5+/- dHet B-ALL cell lines were established using bone marrow CD19+AA4.1hi cells.
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| |
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| Contributor(s) |
Ramamoorthy S, Boller S, Kometani K, Grosschedl R |
| Citation(s) |
33004416 |
| |
| Submission date |
Sep 28, 2020 |
| Last update date |
Oct 19, 2020 |
| Contact name |
Senthilkumar Ramamoorthy |
| E-mail(s) |
senthilkumar@ie-freiburg.mpg.de
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| Phone |
00497615108731
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| Organization name |
Max Planck Institute of Immunobiology and Epigenetics
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| Department |
Cellular & Molecular Immunology
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| Lab |
Laboratory Rudolf Grosschedl
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| Street address |
Stübeweg 51
|
| City |
Freiburg |
| ZIP/Postal code |
D-79108 |
| Country |
Germany |
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| Platforms (3) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (21)
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| This SubSeries is part of SuperSeries: |
| GSE158673 |
EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression and folate metabolism |
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| Relations |
| BioProject |
PRJNA666169 |
| SRA |
SRP285648 |
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