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| Status |
Public on Oct 12, 2021 |
| Title |
Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Previous studies suggested that XBP1s is important in deciding cell fate during the UPR, however, the mechanistic details of how it modulates this transition are limited. To search for XBP1s transcriptional targets, we utilized an XBP1s-inducible human cell line to limit XBP1 expression in a controlled manner.
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| Overall design |
Examination of XBP1s and XBP1u transcriptional activity in dedicated inducible HeLa cell lines.
GRANT: This research was funded by National Science Center "OPUS" Program under contract UMO-2020/37/B/NZ3/00861 to Rafal Bartoszewski
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| Contributor(s) |
Bartoszewski R |
| Citation(s) |
34636989 |
| |
| Submission date |
Oct 29, 2020 |
| Last update date |
Oct 25, 2021 |
| Contact name |
Rafal A Bartoszewski |
| Organization name |
Medical University of Gdansk
|
| Street address |
Hallera 107
|
| City |
GDANSK |
| ZIP/Postal code |
80-416 |
| Country |
Poland |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA673178 |
| SRA |
SRP289775 |
