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| Status |
Public on Jan 11, 2021 |
| Title |
Type 2 Diabetes Mellitus is Associated with Transcriptome Alterations in Cortical Neurones and Associated Neurovascular Unit Cells in the Ageing Brain |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes in cortical neurones, and associated astrocytes and endothelial cells of the neurovascular unit, in the ageing brain
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| Overall design |
Neurone, astrocyte, and endothelial cell-enriched RNA, obtained by immuno-laser capture microdissection of temporal cortex (Brodmann area 21/22) from 6 cases with self-reported T2D in the Cognitive Function and Ageing Study neuropathology cohort, and 5 age and sex-matched controls, was hybridised onto Affymetrix GeneChip® HG-U133 Plus 2.0 arrays.
Expression profiling of Human brain Neurone, astrocyte, and endothelial cell-enriched RNA, obtained by immuno-laser capture microdissection of temporal cortex
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| Contributor(s) |
Bury JJ, Chambers A, Heath PR, Ince PG, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB |
| Citation(s) |
33407907 |
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| Submission date |
Nov 12, 2020 |
| Last update date |
Jan 11, 2021 |
| Contact name |
Paul Roy Heath |
| E-mail(s) |
p.heath@sheffield.ac.uk
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| Phone |
+44 114 2222254
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| Organization name |
University of Sheffield
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| Department |
Academic Neurology Unit
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| Lab |
Heath
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| Street address |
SITraN, 385a Glossop Road
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| City |
Sheffield |
| State/province |
S. Yorks |
| ZIP/Postal code |
S10 2HQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (33)
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| Relations |
| BioProject |
PRJNA677949 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE161355_RAW.tar |
137.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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