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| Status |
Public on Nov 01, 2023 |
| Title |
Otsuka Long-Evans Tokushima fatty rats with Roux-en-Y gastric bypass surgery |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Objective: The mechanisms underlying type 2 diabetes resolution after Roux-en-Y gastric bypass (RYGB) are unclear. We previously observed temporal migrations in small intestinal glycolysis, suggesting that glucose excretion may contribute to glucose homeostasis. This study aimed to evaluate the mechanisms underlying serum glucose excretion and its contribution to glucose homeostasis by using 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) positron emission tomography. Design: FDG distribution in reconstructed intestinal limbs of sham- or RYGB-operated obese rats was identified. RNA sequencing was performed in areas of high or low FDG uptake.
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| Overall design |
RNA-seq was performed to investigate the relative effects of RYGB gastric bypass intervention on the small intestine. N=3 replicates were profiled.
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| Contributor(s) |
Ku C, Cho A, Kang C, Kwon I |
| Citation missing |
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| |
| Submission date |
Nov 13, 2020 |
| Last update date |
Nov 01, 2023 |
| Contact name |
Chan Woo Kang |
| E-mail(s) |
azaapower1@gmail.com
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| Organization name |
Yonsei University
|
| Street address |
50 Yonsei-ro Seodaemun-gu
|
| City |
Seoul |
| State/province |
Seoul |
| ZIP/Postal code |
03722 |
| Country |
South Korea |
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| Platforms (1) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA678226 |
| SRA |
SRP292476 |
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