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| Status |
Public on Apr 01, 2022 |
| Title |
Knockdown of Ino80 complex subunits Actr5, Ies6, and Ino80 in RD cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
INO80 complex is an ATPase-dependent chormatin remodeling complex, which regulates various DNA metabolic processes such as DNA replication and repair. Additionally, INO80 complex also contributes to the regulation of gene expression in sterss response and development. In order to investigate the function of INO80 complex in rhabdomyosarcoma, we examined the knockdown of subunits of INO80 complex Actr5, Ies6, and Ino80 in human rhabdomyosarcoma RD cells. As a result, it was found that INO80 complex is involved in the sarcomagenicity and the disregulation of myogenic properties of rhabdomyosarcoma cells.
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| Overall design |
Subunits of INO80 complex Actr5, Ies6, and Ino80 were knocked down in RD cells, respectively.
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| Contributor(s) |
Morita T, Hayashi K |
| Citation(s) |
35348112 |
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| Submission date |
Mar 25, 2021 |
| Last update date |
Apr 19, 2022 |
| Contact name |
Tsuyoshi Morita |
| E-mail(s) |
tsuyo@wakayama-med.ac.jp
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| Organization name |
Wakayama Medical University
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| Department |
Department of Biology
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| Street address |
Mikazura 580
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| City |
Wakayama |
| ZIP/Postal code |
6410011 |
| Country |
Japan |
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| Platforms (1) |
| GPL20844 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Feature Number Version] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA717367 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE169681_RAW.tar |
22.4 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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