|
| Status |
Public on Nov 17, 2021 |
| Title |
NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome [CWR22_EPIC] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global functions and overall contributions to PCa progression remain enigmatic. We mapped the dihydrotestosterone (DHT) dependent and independent effects of NCOR2 on the transcriptome, cistrome and DNA methylome in androgen sensitive (AS) and ADT-RPCa cells using the isogenic LNCaP and LNCaP-C4-2 (C4-2) cell models and the CWR22 xenograft model of ADT-RPCa.
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| |
|
| Overall design |
Bisulphite converted DNA from CWR22 xenograft samples were hybridised to the Illumina Infinium HumanMethylation850 BeadChip
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| |
|
| Contributor(s) |
Smiraglia DJ, Campbell MJ, Long MD |
| Citation(s) |
34910907 |
| |
| Submission date |
Jun 24, 2021 |
| Last update date |
Feb 16, 2022 |
| Contact name |
Mark D Long |
| E-mail(s) |
mark.long@roswellpark.org
|
| Organization name |
Roswell Park Comprehensive Cancer Center
|
| Department |
Bioinformatics & Biostatistics
|
| Street address |
Elm & Carlton Streets
|
| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14263 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL23976 |
Illumina Infinium HumanMethylation850 BeadChip |
|
| Samples (32)
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| This SubSeries is part of SuperSeries: |
| GSE178820 |
NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome |
|
| Relations |
| BioProject |
PRJNA741201 |
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