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| Status |
Public on Oct 13, 2021 |
| Title |
endometrial microbiome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The gut-uterus axis plays a pivotal role in the pathogenesis of endometrial cancer (EC). However, the correlations between the endometrial microbiome and endometrial tumor transcriptome in patients with EC and the impact of the endometrial microbiota on hematological indicators have not been thoroughly clarified. In this prospective study, endometrial tissue samples collected from EC patients (n = 30) and healthy volunteers (n = 10) were subjected to 16S rRNA sequencing of the microbiome. The 30 paired tumor and adjacent nontumor endometrial tissues from the EC group were subjected to RNAseq.
Result: We found that Pelomonas and Prevotella were enriched in the EC group with a high tumor burden. Further transcriptome analysis identified 8 robust associations between Prevotella and fibrin degradation-related genes expressed within ECs.
Conclusions: Our results suggest that the increasing abundance of Prevotella in endometrial tissue combined with high serum DD and FDP contents may be important factors associated with tumor burden.
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| Overall design |
A total of 60 samples including 30 paired tumor and adjacent nontumor endometrial tissues are analyzed.
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| Contributor(s) |
Li C, Gu Y, He Q, Huang J, Song Y, Wan X, Li Y |
| Citation(s) |
34621695 |
| BioProject |
PRJNA757964 |
| |
| Submission date |
Sep 01, 2021 |
| Last update date |
Oct 13, 2021 |
| Contact name |
CHAO LI |
| E-mail(s) |
lichao126688@126.com
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| Phone |
18817867662
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| Organization name |
Shanghai First Maternity and Infant Hospital
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| Street address |
No. 2699, West GaoKe Road
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| City |
Shanghai |
| ZIP/Postal code |
201204 |
| Country |
China |
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| Platforms (1) |
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| Samples (60)
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