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Series GSE185622 Query DataSets for GSE185622
Status Public on Oct 15, 2021
Title Microglial-expressed Apoe does not modulate plaque pathogenesis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary This dataset allows for the exploration of the effect of microglial-expressed Apoe knockout in a 5xFAD Alzheimer's Disease model.
 
Overall design Mice hippocampi were sequenced in the following groups at 4 and 12 months of age: 1. Apoe(fl/fl) 2. Apoe(fl/fl) Csf1r-cre 3. Apoe(fl/fl) 5xFAD 4. Apoe(fl/fl) 5xFAD Csf1r-Cre. Microglial-expressed Apoe was knocked out of mice that are homozygous for Apoe(fl/fl) and hemizygous for Csf1r-cre. n=3-8 for each group
 
Contributor(s) Green KN, Henningfield CM, Soni N
Citation(s) 34643971
Submission date Oct 10, 2021
Last update date Jan 14, 2022
Contact name Kim Green
E-mail(s) kngreen@uci.edu
Phone 9498243859
Organization name University of California, Irvine
Department Neurobiology and Behavior
Street address 3208 Biological Sciences 3
City Irvine
State/province CA
ZIP/Postal code 92617
Country USA
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (45)
GSM5620774 4mo Apoe(fl/fl) Hippocampus 1
GSM5620775 4mo Apoe(fl/fl) Hippocampus 2
GSM5620776 4mo Apoe(fl/fl) Hippocampus 3
Relations
BioProject PRJNA770093
SRA SRP340750

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE185622_TPM.xls.gz 7.7 Mb (ftp)(http) XLS
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
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