|
| Status |
Public on Feb 28, 2022 |
| Title |
Degradation of the E. coli essential proteins DapB and Dxr results in oxidative stress which contributes 2 to the lethality through incomplete BER |
| Organism |
Escherichia coli |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We identified two new lethal stresses whose depletion results in bacterial cell death at least partially through incomplete BER. We confirmed that this pathway is causal to cell death and compared the various physiological changes that occur as a consequence of depletion of these two essentially proteins.
|
| |
|
| Overall design |
Gene expression comparison of DapB and Dxr depleted cells at two and three hours post induction of the protease
|
| |
|
| Contributor(s) |
Gruber CC, Walker GC |
| Citation(s) |
35130721 |
| |
| Submission date |
Dec 20, 2021 |
| Last update date |
May 31, 2022 |
| Contact name |
Charley Gruber |
| E-mail(s) |
cgruber@mit.edu
|
| Organization name |
UTSW
|
| Department |
Microbiology
|
| Lab |
Sperandio
|
| Street address |
6000 Harry Hines
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75235 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL14548 |
Illumina HiSeq 2000 (Escherichia coli) |
|
| Samples (14)
|
|
| Relations |
| BioProject |
PRJNA790969 |
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