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| Status |
Public on Dec 31, 2012 |
| Title |
Gene expression analysis of HepaRG cells that ectopically express miR-371-3 cluster |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
the immoratlized hepatic cell line HepaRG was transduced with a retroviral vector containing the miR-371-3 cluster. As a control, transduction was performed with the empty vector. Transcriptome analysis was performed by using the Affymetrix whole-transcript human gene 1.0 ST array. Each condition was analyzed in triplicate
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| Overall design |
hierarchical unsupervised clustering of HB samples according to their miRNA expression profile identifies 2 tumor subgroups associated with different degree of differentiation, proliferation rate and invasive phenotype. As subset of these tumors is used as training set to build a mir classifier. When the signature is applied to an independent test set, an independent series of HB is classified patients into two groups associated with the clinical features identified in the first set of patients.
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| Contributor(s) |
Cairo S, Buendia M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 26, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
stefano cairo |
| E-mail(s) |
stefano.cairo@gmail.com
|
| Organization name |
Xentech
|
| Street address |
4 rue Pierre Fontaine
|
| City |
Evry |
| ZIP/Postal code |
91000 |
| Country |
France |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE21085 |
Analysis of Hepatoblastoma and normal fetal liver miRNA profiles and HepaRG cells that ectopically express miR-371-3 cluster |
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| Relations |
| BioProject |
PRJNA129679 |
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