|
| Status |
Public on Aug 30, 2023 |
| Title |
Dosage compensation of Z sex chromosome genes in avian fibroblast cells |
| Organisms |
Dromaius novaehollandiae; Anas platyrhynchos; Gallus gallus; Pavo cristatus; Meleagris gallopavo; Taeniopygia guttata; Coturnix japonica |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Sex in birds is genetically determined, molecular mechanism of which is not well-understood. Their Z sex chromosome (chrZ) lacks whole chromosome inactivation as known for mammalian chrX. To investigate the extent of chrZ dosage compensation and its role in somatic cell’s sex specification, we used a highly-quantitative method and analyzed transcriptional activities of male and female fibroblasts from seven birds. Our data indicate for the first time that ¾ of chrZ genes are strictly compensated, similar to that observed in chrX. We also describe non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a candidate for universal, sex-dimorphic genes in birds.
|
| |
|
| Overall design |
Embryonic fibroblast cultures for seven bird species (chicken, quail, turkey, peacock, duck, zebra finch, and emu) obtained from males and females. At least two replicates.
|
| |
|
| Contributor(s) |
Deviatiiarov R, Nagai H, Ismagulov G, Stupina A, Wada K, Sukparangsi W, Intarapat S, Gusev O, Sheng G, Ide S, Toji N, Zhang H |
| Citation(s) |
37730643 |
| |
| Submission date |
Sep 13, 2022 |
| Last update date |
Sep 23, 2023 |
| Contact name |
Ruslan Deviatiiarov |
| E-mail(s) |
ruselusalbus@gmail.com
|
| Phone |
+79196948678
|
| Organization name |
Kazan Federal University
|
| Department |
Institute of Fundamental Medicine and Biology
|
| Lab |
Extreme Biology
|
| Street address |
Paris Commune, 9
|
| City |
Kazan |
| State/province |
Tatarstan |
| ZIP/Postal code |
420021 |
| Country |
Russia |
| |
|
| Platforms (7)
|
| GPL19005 |
Illumina HiSeq 2500 (Gallus gallus) |
| GPL22591 |
Illumina HiSeq 2500 (Anas platyrhynchos) |
| GPL23198 |
Illumina HiSeq 2500 (Taeniopygia guttata) |
| GPL28636 |
Illumina HiSeq 2500 (Meleagris gallopavo) |
| GPL32659 |
Illumina HiSeq 2500 (Pavo cristatus) |
| GPL32660 |
Illumina HiSeq 2500 (Dromaius novaehollandiae) |
| GPL32661 |
Illumina HiSeq 2500 (Coturnix japonica) |
|
| Samples (54)
|
|
| Relations |
| BioProject |
PRJNA880269 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE213253_Chicken_CAGE.xlsx |
1.2 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Chicken_RNAseq.xlsx |
1.0 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Duck_CAGE.xlsx |
1.2 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Duck_RNAseq.xlsx |
1.0 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Emu_CAGE.xlsx |
1.3 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Emu_RNAseq.xlsx |
1.0 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Peacock_CAGE.xlsx |
1.0 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Peacock_RNAseq.xlsx |
997.7 Kb |
(ftp)(http) |
XLSX |
| GSE213253_Quail_CAGE.xlsx |
1.3 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Quail_RNAseq.xlsx |
936.4 Kb |
(ftp)(http) |
XLSX |
| GSE213253_Turkey_CAGE.xlsx |
1.4 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Turkey_RNAseq.xlsx |
942.9 Kb |
(ftp)(http) |
XLSX |
| GSE213253_ZebraFinch_CAGE.xlsx |
1.3 Mb |
(ftp)(http) |
XLSX |
| GSE213253_Zebrafinch_RNAseq.xlsx |
967.7 Kb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
Less...
More...