|
| Status |
Public on Feb 03, 2023 |
| Title |
Expression data from PBMCs in patients with CHB or SC HBV |
| Platform organisms |
Homo sapiens; synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
|
| Summary |
There were 3 patients with CHB and 3 patients with SC HBV in microarray analysis. As for the liver function parameters, the average HBsAg and HBeAg levels of CHB group were obviously higher than SC HBV group.
The obtained RNAs expression profiles were analyzed by microarray analysis. A total of 513 lncRNAs, 256 mRNAs and 48 miRNAs were found to be differentially expressed (DE) in patients with CHB compared with patients with SC HBV (fold change > 1.2 and P < 0.05).
|
| |
|
| Overall design |
The peripheral blood mononuclear cells (PBMCs) were obtained from three patients with SC HBV and three patients with CHB. Total RNA was isolated using miRNeasy Mini Kit (QIAGEN, Hilden, Germany) according to the manufacturer’s instructions.
|
| |
|
| Contributor(s) |
Chen J, Wang S |
| Citation(s) |
36845111 |
| |
| Submission date |
Feb 01, 2023 |
| Last update date |
Mar 09, 2023 |
| Contact name |
Chengxia Xie |
| E-mail(s) |
chengxia_xie@163.com, xiechengxiascu@scu.edu.cn
|
| Organization name |
Sichuan University
|
| Street address |
Wangjiang Campus, Sichuan University, Wuhou District
|
| City |
Chengdu |
| ZIP/Postal code |
610041 |
| Country |
China |
| |
|
| Platforms (2) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA930458 |
Less...
More...