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| Status |
Public on Aug 16, 2023 |
| Title |
Expression data from primary human lung MVPC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
MVPC isolated from explanted lung tissue at VUMC.; Control MVPC - 3 independent patients, mTOR activated MVPC - 3 lines 1 patient; Fetal 3 independent patients. Fetal lung MSC 3 independent patients LAM MVPC - 1 patient 3 different parts of lung; Fetal lung MVPC 3 independent patients; Control MVPC - 3 independent patients
To elucidate pathways in human MVPC that were affected by mTOR activation, transcriptome expression analysis via microarray comparing primary human lung MVPC from normal control, mTOR+ and fetal lung was performed. Following normalization, hierarchical clustering analyses were presented as a heatmap (Figure 2A; Supplemental Figure 4), illustrating significant differences between the mTOR activated MVPC and normal controls. Interestingly, mTOR activated MVPC patterns of gene expression overlapped approximately 33% with the fetal lung MVPC
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| |
|
| Overall design |
Human Affy 1.0 st chips; CU AMC Genomics Core 2016
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| |
|
| Contributor(s) |
Majka S, Menon S |
| Citation(s) |
37874650 |
| |
| Submission date |
Feb 21, 2023 |
| Last update date |
Oct 31, 2023 |
| Contact name |
Susan M Majka |
| E-mail(s) |
majkas@njhealth.org, susanmajka@mac.com
|
| Organization name |
NJH
|
| Department |
Medicine
|
| Street address |
1400 Jackson St, Goodman Bldg K810a
|
| City |
Denver |
| State/province |
co |
| ZIP/Postal code |
80206 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA937295 |
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