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| Status |
Public on Mar 07, 2023 |
| Title |
Integrating transcriptomics and metabolomics to analyze the mechanism of hypertension-induced hippocampal injury |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Hypertension-induced damage to the hippocampus not only leads to behavioral changes, but also to various brain diseases, but the mechanisms underlying hippocampal lesions are still unclear.
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| Overall design |
The 32-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were selected as the study subjects. The behavioral characteristics of rats were evaluated by behavioral experiments and comprehensive transcriptomic and metabolomic analysis was performed. Comprehensive analysis showed that hypertension-induced hippocampal lesions are closely associated with the metabolites and genes.
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| Contributor(s) |
Li Y, Xie D, Li L, Jiang P |
| Citation missing |
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| |
| Submission date |
Mar 06, 2023 |
| Last update date |
Mar 09, 2023 |
| Contact name |
manman Wang |
| E-mail(s) |
mm-wang@ahtcm.edu.cn
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| Organization name |
Anhui University of Chinese Medicine
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| Street address |
103 Meishan Road
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| City |
Hefei |
| ZIP/Postal code |
230038 |
| Country |
China |
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| Platforms (1) |
| GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA941292 |
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