 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Mar 30, 2023 |
| Title |
RNA sequencing of paVICs exposed to LPC and dantrolene |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the gene expression changes due to LPC-induced calcific nodule formation in porcine aortic valve interstitial cells (paVICs).
We then examined differential gene expression due to treatment with dantrolene, which inhibits calcific nodule formation, with and without LPC after 24 hours of exposure.
|
| |
|
| Overall design |
Comparative gene expression profiling analyis of RNA-seq data for primary paVICs.
|
| Web link |
http:// https://doi.org/10.3389/fcvm.2023.1112965
|
| |
|
| Contributor(s) |
Sylvester CB, Bortoletto AS, Connell JP, Grande-Allen KJ |
| Citation(s) |
37063962 |
| |
| Submission date |
Mar 13, 2023 |
| Last update date |
May 03, 2023 |
| Contact name |
K. Jane Grande-Allen |
| E-mail(s) |
grande@rice.edu
|
| Organization name |
Rice University
|
| Department |
Bioengineering
|
| Lab |
Matrix Mechanics Laboratory
|
| Street address |
6500 Main St
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL26351 |
Illumina NovaSeq 6000 (Sus scrofa) |
|
| Samples (12)
|
| GSM7093504 |
paVICs, DMSO+LPC, rep1 |
| GSM7093505 |
paVICs, DMSO+LPC, rep2 |
| GSM7093506 |
paVICs, DMSO+LPC, rep3 |
| GSM7093507 |
paVICs, dantrolene+ethanol, rep1 |
| GSM7093508 |
paVICs, dantrolene+ethanol, rep2 |
| GSM7093509 |
paVICs, dantrolene+ethanol, rep3 |
| GSM7093510 |
paVICs, dantrolene+LPC, rep1 |
| GSM7093511 |
paVICs, dantrolene+LPC, rep2 |
| GSM7093512 |
paVICs, dantrolene+LPC, rep3 |
|
| Relations |
| BioProject |
PRJNA944185 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE227229_CAVD_annot_combat.csv.gz |
598.1 Kb |
(ftp)(http) |
CSV |
| GSE227229_CAVD_annot_combat_DEgenes_DANvVEH.csv.gz |
945.2 Kb |
(ftp)(http) |
CSV |
| GSE227229_CAVD_annot_combat_DEgenes_LPCDANvLPC.csv.gz |
919.0 Kb |
(ftp)(http) |
CSV |
| GSE227229_CAVD_annot_combat_DEgenes_LPCDANvVEH.csv.gz |
923.2 Kb |
(ftp)(http) |
CSV |
| GSE227229_CAVD_annot_combat_DEgenes_LPCvVEH.csv.gz |
950.7 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...