|
| Status |
Public on Aug 27, 2010 |
| Title |
Functional blockade of α5β1 integrin induces scattering and genomic landscape remodeling of hepatic progenitor cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Cells treated with a specific antibody against α5β1 integrin exhibited cell spreading and scattering, over-expression of liver stem/progenitor cell markers and activation of the ERK1/2 and p38 MAPKs signaling cascades, in a similar manner to the process triggered by HGF/SF1 stimulation. Gene expression profiling revealed marked transcriptional changes of genes involved in cell adhesion and migration, as well as genes encoding chromatin remodeling factors. These responses were accompanied by conspicuous spatial reorganization of centromeres, while integrin genes conserved their spatial positioning in the interphase nucleus.
|
| |
|
| Overall design |
Untreated cells versus HGF/SF1 treated or α5β1 integrin-mediated cell migration
|
| |
|
| Contributor(s) |
Vellón L, Parada LA |
| Citation(s) |
20958983 |
| |
| Submission date |
Aug 27, 2010 |
| Last update date |
Aug 28, 2019 |
| Contact name |
Rune Matthiesen |
| E-mail(s) |
runem2009@gmail.com
|
| Organization name |
IPATIMUP
|
| Lab |
Population Genetics
|
| Street address |
Rua Dr. Roberto Frias s/n
|
| City |
Porto |
| ZIP/Postal code |
4200-465 |
| Country |
Portugal |
| |
|
| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA130557 |
Less...
More...