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| Status |
Public on Sep 03, 2010 |
| Title |
DNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
We performed DNA methylation (HELP) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL were assigned to the 69 DLBCL cases. Then, we performed supervised analysis using HELP data and defined DNA methylation signature differentiating 2 subgroups of DLBCLs.
Keywords: DNA methylation profiling
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| Overall design |
The retrospective study included DNA extracted from 69 clinical samples.
[This Series represents the DNA methylation profiling component of the study.]
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| Contributor(s) |
Melnick A, Gascoyne R, Elemento O, Shaknovich R, Geng H |
| Citation(s) |
20610814 |
| |
| Submission date |
Sep 03, 2010 |
| Last update date |
Mar 22, 2012 |
| Contact name |
Rita Shaknovich |
| E-mail(s) |
ris9004@med.cornell.edu
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| Organization name |
Weill Cornell Medical Center
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| Department |
Medicine
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| Lab |
Dr.Melnick
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| Street address |
1300 York Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
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| Platforms (1) |
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| Samples (69)
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| Relations |
| BioProject |
PRJNA130399 |
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