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Status |
Public on Sep 03, 2010 |
Title |
DNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by genome tiling array
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Summary |
We performed DNA methylation (HELP) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL were assigned to the 69 DLBCL cases. Then, we performed supervised analysis using HELP data and defined DNA methylation signature differentiating 2 subgroups of DLBCLs. Keywords: DNA methylation profiling
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Overall design |
The retrospective study included DNA extracted from 69 clinical samples.
[This Series represents the DNA methylation profiling component of the study.]
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Contributor(s) |
Melnick A, Gascoyne R, Elemento O, Shaknovich R, Geng H |
Citation(s) |
20610814 |
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Submission date |
Sep 03, 2010 |
Last update date |
Mar 22, 2012 |
Contact name |
Rita Shaknovich |
E-mail(s) |
ris9004@med.cornell.edu
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Organization name |
Weill Cornell Medical Center
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Department |
Medicine
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Lab |
Dr.Melnick
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Street address |
1300 York Avenue
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City |
New York |
State/province |
NY |
ZIP/Postal code |
10021 |
Country |
USA |
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Platforms (1) |
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Samples (69)
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Relations |
BioProject |
PRJNA130399 |