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| Status |
Public on Nov 11, 2023 |
| Title |
METTL16 deficiency attenuates apoptosis through translational control of extrinsic death receptor during nutrient deprivation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
METTL16 is a well-characterized m6A methyltransferase that has been reported to contribute to tumorigenesis in various types of cancer. However, the effect of METTL16 on tumor progression under restricted nutrient conditions, which commonly occur in tumor microenvironment, has yet to be elucidated. Herein, our study initially reported the inhibitory effect of METTL16 depletion on apoptosis under amino acid starvation conditions.
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| Overall design |
To investigate the potential role of METTL16 under nutrient deprivation, stable METTL16-knockdown (M16-KD) cell lines were initially constructed using two classic A549 NSCLC cells, through a shRNA-based gene interference approach.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/38520913/
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| |
|
| Contributor(s) |
Li Q, Zhang J |
| Citation(s) |
38520913 |
| |
| Submission date |
Oct 08, 2023 |
| Last update date |
Jun 22, 2024 |
| Contact name |
Zhang Jun |
| E-mail(s) |
3219030654@stu.cpu.edu.cn
|
| Phone |
15651718659
|
| Organization name |
China Pharmaceutical University
|
| Lab |
zhoulab
|
| Street address |
longmiandadao
|
| City |
nanjing |
| State/province |
jiangsu |
| ZIP/Postal code |
211198 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1025878 |
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