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| Status |
Public on Aug 24, 2011 |
| Title |
Gene expression data of BCR-ABL1 transformed myeloid cells from BCL6 wild-type and BCL6 knockout mice treated with and without Imatinib and RI-BPI |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify differences in the gene regulation between BCL6+/+ and BCL6-/- CML cells a gene expression analysis has been performed. We investigated the gene expression pattern in BCL6+/+ cells in the presence or absence of Imatinib and a combination of Imatinib and RI-BPI (a novel retro-inverso BCL6 peptide inhibitor). In BCL6-/- CML cells, we investigated the gene expression pattern in the presence or absence of Imatinib.
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| Overall design |
BCR-ABL1 transformed myeloid cells from BCL6+/+ mice were cultured in the presence or absence of 10µM Imatinib or 10µM Imatinib and 20µM RI-BPI for 16 hours. BCR-ABL1 transformed myeloid cells from BCL6-/- mice were cultured in the presence or absence of 10µM Imatinib. Two samples for each condition were processed.
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| |
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| Contributor(s) |
Hurtz C |
| Citation(s) |
21911423 |
| |
| Submission date |
Oct 19, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Markus Müschen |
| E-mail(s) |
mmuschen@chla.usc.edu
|
| Phone |
+ 1 323 361 5592
|
| Fax |
+1 323 361 1516
|
| URL |
http://www.lymphocytes.de/
|
| Organization name |
University of Southern California
|
| Department |
Childrens Hospital Los Angeles
|
| Lab |
Müschen Lab
|
| Street address |
4650 Sunset Blvd
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90027 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (10)
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| Relations |
| BioProject |
PRJNA132311 |
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