|
| Status |
Public on Oct 21, 2011 |
| Title |
Coordinated regulation of polycomb group complexes through microRNAs in cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
|
| Summary |
To determine the altered mRNA expression signatures upon overexpressing EZH2 regulated microRNAs in cancer. To identify EZH2 regulated microRNAs in cancer.
|
| |
|
| Overall design |
Two-condition experiment: Each EZH2 microRNA was overexpressed and compared to a control RNA in BT549 breast cancer cells. In DU145 prostate cancer cell EZH2 was knocked down and comapred to EZH2 scrambled siRNA. Other cell lines were monitored for miRNA expression as they are known to have high endogenous levels of EZH2.
|
| |
|
| Contributor(s) |
Maher CA |
| Citation(s) |
21840484 |
| |
| Submission date |
Feb 01, 2011 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Christopher Maher |
| E-mail(s) |
chrmaher@med.umich.edu
|
| Phone |
734-764-3336
|
| Organization name |
Michigan Center for Translational Pathology
|
| Street address |
1500 E. Medical Center Drive
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48105 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
| GPL8178 |
Illumina Human v1 MicroRNA expression beadchip |
|
| Samples (32)
|
|
| Relations |
| BioProject |
PRJNA136937 |
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