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| Status |
Public on Aug 27, 2024 |
| Title |
LncRNA expression profile is associated with neoadjuvant chemotherapy resistance in luminal B breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose: Identified the expression profile of lncRNAs associated to neoadjuvant chemotherapy response in 47 luminal B tumors of locally advanced breast cancer patients
Methods: We implemented the transcriptomic analysis from 47 luminal B breast cancer samples by paired-end RNA-Seq, as a case-control study (responders vs nonresponders group). Differential expression analysis for lncRNA and mRNA were made to identify lncRNA as predictive biomarkers.
Results: We identified a signature of lncRNAs associated with nonresponders group. Additionally, we identified the pathways were differentially expressed lncRNA and mRNA are associated in neoadjuvant chemotherapy response. Additionally, we proposed the clinical application of lncRNA GATA3-AS1 as a predictive biomarker to neoadjuvant chemotherapy response in luminal B breast cancer patients detected by RNA-ISH.
Conclusion: we propose the clinical utility of lncRNA GATA3-AS1 detected by RNA-ISH to identify luminal B breast cancer patients that will not respond to neoadjuvant chemotherapy.
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| Overall design |
Transcriptomic analysis of 47 tumor samples from luminal B breast cancer mexican patients in a case-control study (responders vs nonresponders group), in order to identify lncRNA associated to neoadjuvant chemotherapy response.
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| Contributor(s) |
González-Woge M, Contreras-Espinosa L, Antonio García-Gordillo J, Aguilar-Villanueva S, Bargallo-Rocha E, Cabrera-Galeana P, Vasquez-Mata T, Cervantes-López X, Sofía Vargas-Lías D, Montiel-Manríquez R, Bautista-Hinojosa L, Rebollar-Vega R, Castro-Hernández C, María Álvarez-Gómez R, Alberto De La Rosa-Velázquez I, Jiménez-Trejo F, Arriaga-Canon C, Alonso Herrera L |
| Citation(s) |
39125649 |
| |
| Submission date |
Jun 27, 2024 |
| Last update date |
Aug 27, 2024 |
| Contact name |
Cristian Arriaga |
| E-mail(s) |
cristiancanon@hotmail.com
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| Organization name |
Mexican National Cancer Institute
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| Street address |
AV. SAN FERNANDO, COL. SECCIÓN XVI
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| City |
TLALPAN |
| State/province |
Federal District |
| ZIP/Postal code |
14080 |
| Country |
Mexico |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA1129126 |
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