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| Status |
Public on Mar 17, 2011 |
| Title |
CNVs in spermatogenic failure |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
To determine the involvement of Copy Number Variants (CNVs) in the origin of male infertility, patients with idiopathic severe oligozoospermia, Sertoli-cell-only syndrome and controls with normozoospermia were analysed by array CGH using the 244A/400K array sets (Agilent Technologies).
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| Overall design |
Comparison of 89 infertile male patients with severe oligozoospermia (≤5 x Mill./ml sperm concentration and ≤10 Mill. total sperm count) and 37 with azoospermia due to complete, bilateral Sertoli-cell-only syndrome (SCOS) with 100 healthy controls with normal semen parameters (≥20 Mill./ml sperm concentration, ≥40 Mill. total sperm count, ≥2 ml semen volume, ≥50% of a+b or ≥25% a motility, high percentage of normal forms (≥10%)). Patients with recurring, patient-specific and mostly private, sex-chromosomal CNVs (29 with OAT and 17 with SCOS) are reported as possibly causing spermatogenic failure.
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| Contributor(s) |
Tüttelmann F, Röpke A |
| Citation(s) |
21559371 |
| |
| Submission date |
Mar 15, 2011 |
| Last update date |
Mar 21, 2017 |
| Contact name |
Frank Tüttelmann |
| E-mail(s) |
frank.tuettelmann@ukmuenster.de
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| Organization name |
Institute of Human Genetics
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| Department |
University of Münster
|
| Street address |
Vesaliusweg 12-14
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| City |
Münster |
| ZIP/Postal code |
48149 |
| Country |
Germany |
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| Platforms (2) |
| GPL4091 |
Agilent-014693 Human Genome CGH Microarray 244A (Feature number version) |
| GPL9777 |
Agilent-021850 SurePrint G3 Human CGH Microarray (Feature Number version) |
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| Samples (46)
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| Relations |
| BioProject |
PRJNA137757 |
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