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Status |
Public on Jun 20, 2012 |
Title |
Chromosomal aberrations in ETV6/RUNX1 positive cases using high-resolution 244K oligo-based array-CGH |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by genome tiling array
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Summary |
Identification of chromosomal deletion and duplications in childhood acute lymphoblastic leukemia with t(12;21). This study was performed to correlate clinical parameters with chromosomal aberrations by array-CGH and to identify other potential novel cancer genes involved in leukaemia.
In brief, PALL-6 was a Malay male diagnosed with B-ALL, had undergone a remission but late relapse and passed away. He was assessed under medium risk. PALL-7 is a Malay male and has a medium risk assessment, and is currently in remission. PALL-8 is a Malay female and has a medium risk assessment, and is currently in remission. PALL-9 is a Chinese male and has a high risk assessment, and is currently in remission. PALL-10 is a Malay male and has a standard risk assessment, had a relapse but is currently in remission. PALL-11 was a Malay male and had a medium risk assessment, but died during transplant.
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Overall design |
array-CGH was carried out on 11 cases of childhood acute lymphoblastic leukemia with t(12;21) diagnosed by molecular and FISH techniques. Commercial male and female genomic DNA were used as the references.
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Contributor(s) |
Zakaria Z, Kamaluddin NR, Ahid MF, Ahmat N, Sharmiza E |
Citation(s) |
23151340 |
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Submission date |
Oct 11, 2011 |
Last update date |
Sep 17, 2019 |
Contact name |
Zubaidah Zakaria |
E-mail(s) |
zubaidah@imr.gov.my
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Phone |
0326162708
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Fax |
0326162707
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URL |
http://www.imr.gov.my
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Organization name |
Institute for Medical Research
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Department |
Haematology Unit
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Lab |
array CGH Lab
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Street address |
Jalan Pahang
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City |
Kuala Lumpur |
ZIP/Postal code |
50588 |
Country |
Malaysia |
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Platforms (1) |
GPL4091 |
Agilent-014693 Human Genome CGH Microarray 244A (Feature number version) |
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Samples (11)
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GSM814473 |
Acute Lymphoblastic Leukemia Patient 1 |
GSM814474 |
Acute Lymphoblastic Leukemia Patient 2 |
GSM814475 |
Acute Lymphoblastic Leukemia Patient 3 |
GSM814476 |
Acute Lymphoblastic Leukemia Patient 4 |
GSM814477 |
Acute Lymphoblastic Leukemia Patient 5 |
GSM949781 |
Acute Lymphoblastic Leukemia Patient 6 |
GSM949782 |
Acute Lymphoblastic Leukemia Patient 7 |
GSM949783 |
Acute Lymphoblastic Leukemia Patient 8 |
GSM949784 |
Acute Lymphoblastic Leukemia Patient 9 |
GSM949785 |
Acute Lymphoblastic Leukemia Patient 10 |
GSM949786 |
Acute Lymphoblastic Leukemia Patient 11 |
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Relations |
BioProject |
PRJNA146641 |