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| Status |
Public on Dec 01, 2011 |
| Title |
CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
CD133-positive colorectal cancer cells exhibit enhanced tumorigenicity over CD133-negative cells. The CD133+ cells are more interactive with and responsive to their stromal microenvironment because they also express the cognate receptors, such as CXCR4, for ligands produced by their neighboring carcinoma-associated fibroblasts, such as SDF-1 (stromal-derived growth factor).
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| Overall design |
we isolated and separately cultured both the carcinoma cells and CAF from the same patient tumor. Three samples (CD133+, CD133-, Carcinoma associated fibroblasts) in triplicate for a total of 9 samples.
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| Contributor(s) |
Chao C, Carmical JR |
| Citation(s) |
22157717 |
| |
| Submission date |
Nov 30, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Celia Chao |
| E-mail(s) |
cechao@utmb.edu
|
| Phone |
409-772-0698
|
| Organization name |
Univ TX Medical Branch
|
| Department |
Surgery
|
| Street address |
301 University Boulevard
|
| City |
Galveston |
| State/province |
TX |
| ZIP/Postal code |
77555-0737 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA150027 |
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