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Status |
Public on Mar 23, 2012 |
Title |
Gene profiling in mucosal biopsies of Eosinophilic Esophagitis patients pre and post glucocorticoid steroid treatment |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Eosinophlic esophagitis (EoE) is increasely recognized as an antigen-drived disorder. The goal of this study is to reveal the gene expression changes in EoE before and after a successful glucocorticoid steroid treatment. We used microarrays to identify distinct genes involving the pathophysiology of EoE.
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Overall design |
Esophageal mRNA from the epithelial layers of 5 paired paraffin-embedded biopsies before and after treatment with glucocorticosteroids were harvested and profiled using Affymetrix Human Gene 1.0 ST array to generate differentially regulated mRNA transcripts.
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Contributor(s) |
Lu S, Cleveland K, Schorl C, Mukkada VA, Resnick MB |
Citation(s) |
22815788 |
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Submission date |
Mar 22, 2012 |
Last update date |
Jul 26, 2018 |
Contact name |
Shaolei Lu |
E-mail(s) |
slu@lifespan.org
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Phone |
401-444-5709
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Organization name |
Rhode Island Hospital
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Department |
Pathology
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Street address |
593 Eddy Steet
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City |
Providence |
State/province |
Rhode Island |
ZIP/Postal code |
02903 |
Country |
USA |
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Platforms (1) |
GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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Samples (10)
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This SubSeries is part of SuperSeries: |
GSE36727 |
MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Glucocorticoid Steroid Treatment and Relationship with mRNA Target Expression |
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Relations |
BioProject |
PRJNA155461 |