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| Status |
Public on Jun 06, 2006 |
| Title |
Arthritis_RA_OA_VNS |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Pigmented villonodular synovitis (PVNS) represents a rare group of lesions with morphological features suggesting an inflammatory as well as a neoplastic nature. Rheumatoid arthritis (RA) is characterized by a chronic inflammation of the synovial tissue and a tumor-like proliferation (TLP) of synovial stroma cells. Osteoarthritis (OA) shows modest inflammatory infiltrates and no TLP.
All three diseases result in a progressive destruction of affected joints and remain a diagnostic difficulty because of nonspecific symptoms. This study aimed to identify molecular markers and genes correlated with the development of RA, OA, and PVNS using human whole genome cDNA microarrays and tissue samples obtained from knee surgery.
Keywords: disease state analysis
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| Overall design |
This series includes dual channel hybridizations of 48 independent
synovial membrane samples on Unigene3.1 cDNA Arrays. The 48 biopsies were collected from 18 patients with RA, 19 patients with OA and 11 patients with PVNS. For every independent sample, minimum of two technical replicates were performed and further processed as mean values.
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| Contributor(s) |
Finis K, Sultmann H, Ruschhaupt M, Buness A, Kuner R, Berger I, Fink B |
| Citation(s) |
16508983 |
| |
| Submission date |
Nov 30, 2005 |
| Last update date |
Jan 17, 2013 |
| Contact name |
Ruprecht Kuner |
| Organization name |
German Cancer Research Center and National Center of Tumor Diseases
|
| Department |
Molecular Genetics
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| Lab |
Unit Cancer Genome Research
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| Street address |
Im Neuenheimer Feld 460
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL3050 |
Human Unigene3.1 cDNA Array 37.5K v1.0 |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA93847 |
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