|
| Status |
Public on Mar 22, 2013 |
| Title |
Profiling whole lung from lung-specific IL-1b-Tg mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
This program aims at identifying the lung gene signature associated with inflammation and emphysema in IL-1b-Tg mouse COPD model to facilitate understanding of the disease mechanism and therapeutic compound testing
|
| |
|
| Overall design |
The lung profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the lungs of IL-1b-Tg mice treated with doxycycline (to induce IL-1b transgene) compared to the corresponding water-treated controls.
|
| |
|
| Contributor(s) |
Wang I, Zhang B |
| Citation(s) |
22806142 |
| |
| Submission date |
May 21, 2012 |
| Last update date |
Mar 22, 2013 |
| Contact name |
I-Ming Wang |
| E-mail(s) |
i_ming_wang@merck.com
|
| Phone |
215-652-1287
|
| Organization name |
Merck Research Lab
|
| Department |
Genetics and Pharmacogenomics
|
| Lab |
Discovery Pharmacogenomics
|
| Street address |
770 Sumneytown Pike
|
| City |
West Point |
| State/province |
PA |
| ZIP/Postal code |
19486 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6794 |
Rosetta/Merck Mouse RSTA Custom Affymetrix 1.0 microarray |
|
| Samples (8)
|
| GSM934060 |
Control water-treated lung Replicate 1 |
| GSM934063 |
Control water-treated lung Replicate 2 |
| GSM934065 |
Control water-treated lung Replicate 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE31559 |
Various mice and rat tissues subjected to various treatments |
|
| Relations |
| BioProject |
PRJNA167188 |
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