|
| Status |
Public on Mar 07, 2013 |
| Title |
A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
OSCC is associated with substantial mortality and morbidity. In this study, we built on our previous molecular work to identify and validate a prognostic 13-gene signature that showed a higher ability than tumor stage in predicting survival for patients with
HPV-negative oral squamous cell carcinoma (OSCC).
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| |
|
| Overall design |
We previously reported 131 genes to be associated with survival in OSCC patients. In this study, we applied L1/L2-penalized Cox regression models to the Affymetrix array data from 97 HPV-negative OSCC patients on the 131 gene to identify a model for prediction of OSCC-specific survival. We then tested the model in an independent dataset and compared to tumor stage.
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| |
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| Contributor(s) |
Lohavanichbutr P, Mendez E, Holsinger FC, Rue T, Zhang Y, Houck J, Upton MP, Futran N, Schwartz SM, Chen C |
| Citation(s) |
23319825, 35464860 |
| |
| Submission date |
Oct 16, 2012 |
| Last update date |
Apr 27, 2022 |
| Contact name |
Chu Chen |
| Organization name |
Fred Hutchinson Cancer Research Center
|
| Department |
PHS
|
| Street address |
1100 Fairview Ave. N, PO Box 19024, M/S M5-C800
|
| City |
Seattle |
| State/province |
Washington |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (97)
|
|
| Relations |
| BioProject |
PRJNA177687 |
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