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| Status |
Public on Feb 03, 2006 |
| Title |
Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by array
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| Summary |
BACKGROUND: When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. : We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFbeta mutants at similar developmental stages undergoing dauer formation. Many insulin/IGF pathway and other known dauer regulatory genes have changes in expression that suggest strong positive feedback by the TGFbeta pathway. In addition, many insulin-like ligand and novel genes with similarity to the extracellular domain of insulin/IGF receptors have altered expression. We have identified a large group of regulated genes with putative binding sites for the FOXO transcription factor, DAF-16. Genes with DAF-16 sites upstream of the transcription start site tend to be upregulated, whereas genes with DAF-16 sites downstream of the coding region tend to be downregulated. Finally, we also see strong regulation of many novel hedgehog- and patched-related genes, hormone biosynthetic genes, cell cycle genes, and other regulatory genes.
Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc.
Keywords: Logical Set
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| Overall design |
Computed
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| Contributor(s) |
Wang J |
| Citation(s) |
15380030 |
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| Submission date |
Feb 02, 2006 |
| Last update date |
Mar 16, 2012 |
| Organization |
Stanford Microarray Database (SMD) |
| E-mail(s) |
array@genome.stanford.edu
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| Phone |
650-498-6012
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| URL |
http://genome-www5.stanford.edu/
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| Department |
Stanford University, School of Medicine
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| Street address |
300 Pasteur Drive
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (4)
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| Samples (10)
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| GSM95245 |
N2 (green, channel 1) vs daf-8 (red, channel 2) Trial #3 |
| GSM95246 |
N2 (green, channel 1) vs daf-7 (red, channel 2) Trial #4 |
| GSM95247 |
N2 (green, channel 1) vs daf-7 (red, channel 2) Trial #2 |
| GSM95248 |
N2 (green, channel 1) vs daf-8 (red, channel 2) Trial #2 |
| GSM95249 |
N2 (green, channel 1) vs daf-7 (red, channel 2) Trial #1 |
| GSM95250 |
N2 (green, channel 1) vs daf-14 (red, channel 2) Trial #2 |
| GSM95251 |
N2 (green, channel 1) vs daf-14 (red, channel 2) Trial #3 |
| GSM95252 |
N2 (green, channel 1) vs daf-8 (red, channel 2) Trial #4 |
| GSM95253 |
N2 (green, channel 1) vs daf-14 (red, channel 2) Trial #1 |
| GSM95254 |
N2 (green, channel 1) vs daf-7 (red, channel 2) Trial #3 |
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| Relations |
| BioProject |
PRJNA95079 |
| Supplementary data files not provided |
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