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| Status |
Public on Sep 03, 2013 |
| Title |
Gene expression profiling of MDA231, BT549, and SUM159PT cells after selumetinib treatment or DUSP4 siRNA knockdown |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
MDA231, BT549, and SUM159PT basal-like breast cancer cell lines were transfected with non-targeting siRNA (siCONTROL), siRNA targeting DUSP4 (siDUSP4), or siCONTROL + 4 or 24 hr of 1uM selumetinib. Cells were harvested at 96 hr post-siRNA transfection. Data were Log2 RMA normalized.
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| Overall design |
We sought to identify changes in gene expression after MEK inhibition, or after loss of DUSP4 function in breast cancer cell lines.
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| Contributor(s) |
Balko JM, Arteaga CL |
| Citation(s) |
23966295 |
| |
| Submission date |
Oct 24, 2012 |
| Last update date |
Nov 08, 2016 |
| Contact name |
Justin M Balko |
| Organization name |
Vanderbilt University
|
| Department |
Medicine
|
| Lab |
Arteaga
|
| Street address |
777 Preston Research Building
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37232-6307 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11532 |
[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA178228 |
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