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Series GSE41932 Query DataSets for GSE41932
Status Public on Nov 01, 2012
Title Female Mice Lacking p47phox Have Altered Adipose Tissue Gene Expression and are Protected against High Fat-Induced Obesity and Metabolic Syndrome
Organism Mus musculus
Experiment type Expression profiling by array
Summary Oxidative stress in adipose tissue and liver has been linked to the development of obesity. NADPH oxidases (NOX) enzymes are a major source of reactive oxygen species (ROS). The current study was designed to determine if NOX2-generated ROS play a role in development of obesity and metabolic syndrome after high fat feeding. Wild type (WT) mice and mice lacking the cytosolic NOX2 activated protein p47phox (P47KO) were fed AIN-93G diets or high fat diets (HFD) containing 45% fat and 0.5% cholesterol for 13 weeks from weaning. Affymetrix array analysis revealed dramatically less expression of mRNA of genes linked to energy metabolism, adipocyte differentiation (PPARĪ³, Runx2) and fatty acid uptake (CD36, lipoprotein lipase) in fat pads from female HFD-P47KO mice compared to HFD-WT females. These data suggest that NOX2 is an important regulator of metabolic homeostasis and that NOX2-associated ROS plays an important role in development of diet-induced obesity particularly in the female
 
Overall design fat pads from p47phox and wild type fed a high fat or control diet
 
Contributor(s) Ronis MJ, Sharma N, Vantrease J, Borengasser SJ, Ferguson M, Gomez-Acevedo H, Badger TM
Citation(s) 23482812
Submission date Oct 31, 2012
Last update date Feb 11, 2019
Contact name Horacio Gomez-Acevedo
E-mail(s) horacio.g.acevedo@gmail.com
Organization name University of Arkansas for Medical Sciences
Department Biomedical Informatics
Street address 4301 W. Markham St
City Little Rock
State/province Arkansas
ZIP/Postal code 72205
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM1027652 Wild type casein pool1
GSM1027653 Wild type casein pool2
GSM1027654 Wild type casein pool3
Relations
BioProject PRJNA178540

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Supplementary file Size Download File type/resource
GSE41932_RAW.tar 32.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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